Chemotherapy And Antibiotics In Microbiology Pdf
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This book plays an important role in educating antibiotic prescribers—an increasingly challenging task given the rising number of prescribers who never receive formal training in Medicine, Clinical Pharmacology or Medical Microbiology. This is followed by Part 1, which very comprehensively discusses the properties of antimicrobial agents.
Antibiotics are grouped into different chapters from a mechanistic perspective, and basic chemistry, clinical application and pharmacokinetics are very well explained.
The clinical implications of in vitro phenomena are discussed sufficiently to enable appropriate interpretation by clinicians. Junior prescribers will find the prescriber's survival kits and highlighted key points especially useful.
Part 2 tackles antimicrobial resistance, and the size of this problem is made abundantly clear. Although the emergence and spread of resistance are explained at a genetic level and the mechanisms of resistance explored in depth, the clinical implications of resistance are also very well emphasized.
This section closes with an outstanding chapter on the control of resistance, which should provide useful tips to Medical Microbiologists and Antibiotic Pharmacists. The content of this part, together with its prominent position in the book, should leave the antimicrobial prescriber in no doubt as to the critical importance of the issue of resistance and hence the great responsibility borne by every prescriber.
Part 3 superbly bridges the gap between the laboratory and the patient. The importance of timely, appropriate specimens is emphasized, the time frames for preliminary and final results are explained and the importance and difficulties of interpretation discussed. The principles of antimicrobial susceptibility testing are also explained, as is the rationale behind restricted reporting. The second chapter discusses the management of the septic patient, both from clinical and laboratory perspectives, and discusses the use of antibiotics, both in the empirical setting and once microbiological results are available.
Microbiological and financial considerations are discussed, and key pharmacokinetic and pharmacodynamic issues are outlined. The pharmacokinetic, pharmacodynamic and toxicity considerations that surround antimicrobial chemotherapy are explored in far greater depth in the next three chapters, which fulfil an important role in broadening the thinking of the junior prescriber and providing the realization that microbial susceptibility is only one of many steps in planning an antimicrobial treatment regimen.
The next chapter addresses antimicrobial chemoprophylaxis in different settings. Part 3 closes with a chapter on antimicrobial management, outlining different strategies for controlling antibiotic use and the evidence for their effectiveness. This chapter should provide a handy framework for Medical Microbiologists and Antibiotic Pharmacists alike. The final part contains 12 chapters that address the management of specific bacterial, viral and parasitic infections, one of which is dedicated to the immunocompromised host.
Each chapter begins with an excellent overview that outlines key issues surrounding each infection. The clinical assessment, laboratory investigation and microbiology of each infection are then described in both primary and secondary care settings, and antimicrobial management discussed in these very different situations.
The broad approach with which these chapters open neatly tapers to address individual clinical scenarios and should appeal to a wide range of prescribers. The penultimate chapter addresses the use of topical antimicrobial agents, outlining the rationale, discussing the indications and pointing out the hazards.
This area has until recently tended to be brushed aside, and the clear discussion in this book is very welcome. The final chapter in this illuminating book closes with a description of the major issues surrounding the development and marketing of antimicrobial agents, taking into account scientific, ethical and legal issues—this summary will likely interest and inform those involved in discussions with pharmaceutical companies.
This book is an excellent blend of basic science and clinical application; it targets a variety of healthcare professionals and fulfils multiple roles. Whilst providing an everyday guide to the management of infection for the junior prescriber, it should also inform the more experienced clinician seeking a broader and deeper understanding of antimicrobial chemotherapy. The facts are clearly presented using a captivating approach, and the authors have succeeded in imparting a large volume of information in a compact and unintimidating manner.
Contentious issues are well discussed, and balanced arguments fairly presented. Overall, an excellent, up to date text that prescribers of antimicrobial chemotherapy should find invaluable when confronting the challenging issues posed by infections in the current era.
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Sign In or Create an Account. Sign In. Advanced Search. Search Menu. Skip Nav Destination Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents. Article Navigation. Indran Balakrishnan Indran Balakrishnan. Royal Free Hospital.
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IS 26 cannot move alone. Antifungal activity of nikkomycin Z against Candida auris. Allele-based analysis revealed the critical functions of region — in the NorA efflux pump of Staphylococcus aureus.
This book plays an important role in educating antibiotic prescribers—an increasingly challenging task given the rising number of prescribers who never receive formal training in Medicine, Clinical Pharmacology or Medical Microbiology. This is followed by Part 1, which very comprehensively discusses the properties of antimicrobial agents. Antibiotics are grouped into different chapters from a mechanistic perspective, and basic chemistry, clinical application and pharmacokinetics are very well explained. The clinical implications of in vitro phenomena are discussed sufficiently to enable appropriate interpretation by clinicians. Junior prescribers will find the prescriber's survival kits and highlighted key points especially useful. Part 2 tackles antimicrobial resistance, and the size of this problem is made abundantly clear. Although the emergence and spread of resistance are explained at a genetic level and the mechanisms of resistance explored in depth, the clinical implications of resistance are also very well emphasized.
Antibiotics have been used for millennia to treat infections, although until the last century or so people did not know the infections were caused by bacteria. Various moulds and plant extracts were used to treat infections by some of the earliest civilisations — the ancient Egyptians, for example, applied mouldy bread to infected wounds. Nevertheless, until the 20th century, infections that we now consider straightforward to treat — such as pneumonia and diarrhoea — that are caused by bacteria, were the number one cause of human death in the developed world. Paul Ehrlich, a German physician, noted that certain chemical dyes coloured some bacterial cells but not others. He concluded that, according to this principle, it must be possible to create substances that can kill certain bacteria selectively without harming other cells. In , he discovered that a chemical called arsphenamine was an effective treatment for syphilis.
Antimicrobial chemotherapy is the clinical application of antimicrobial agents to treat infectious disease. From Wikipedia, the free encyclopedia. There are five types of antimicrobial chemotherapy: Antibacterial chemotherapy , the use of antibacterial drugs to treat bacterial infections Antifungal chemotherapy , the use of antifungal drugs to treat fungal infections Anthelminthic chemotherapy , the use of antihelminthic drugs to treat worm infections Antiprotozoal chemotherapy , the use of antiprotozoal drugs to treat protozoan infections Antiviral chemotherapy , the use of antiviral drugs to treat viral infections See also [ edit ] Antimicrobial Agents and Chemotherapy British Society for Antimicrobial Chemotherapy Chemotherapy Journal of Antimicrobial Chemotherapy Origin of the term "chemotherapy" Index of articles associated with the same name. Categories : Set indices. Hidden categories: Articles with short description Short description is different from Wikidata All set index articles.
Antibiotic and Chemotherapy
If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus. Please consult the latest official manual style if you have any questions regarding the format accuracy. Drugs have been used for the treatment of infectious diseases since the 17th century eg, quinine for malaria, emetine for amebiasis ; however, chemotherapy as a science began in the first decade of the 20th century with understanding of the principles of selective toxicity, the specific chemical relationships between microbial pathogens and drugs, the development of drug resistance, and the role of combined therapy. Experiments led to the arsphenamines for syphilis, the first planned chemotherapeutic regimen.
The history of antibiotics
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections , and antibiotic medications are widely used in the treatment and prevention of such infections. A limited number of antibiotics also possess antiprotozoal activity. However, both classes have the same goal of killing or preventing the growth of microorganisms, and both are included in antimicrobial chemotherapy. Antibiotics have been used since ancient times.
Капля Росы. Очевидно, она перевела свое имя на единственный язык, равно доступный ей и ее клиенту, - английский. Возбужденный, Беккер ускорил шаги в поисках телефона. По другой стороне улицы, оставаясь невидимым, шел человек в очках в тонкой металлической оправе. ГЛАВА 27 Тени в зале шифровалки начали удлиняться и терять четкость. Автоматическое освещение постепенно становилось ярче. Сьюзан по-прежнему молча сидела за компьютером, ожидая вестей от Следопыта.
Broad-spectrum antibiotics are those that act on both gram-positive and gram-negative bacteria. Chemotherapeutic agent (drug)-any chemical (natural or synthetic).
Хейл невинно улыбнулся: - Просто хотел убедиться, что ноги меня еще носят. - Понимаю. - Стратмор хмыкнул, раздумывая, как поступить, потом, по-видимому, также решил не раскачивать лодку и произнес: - Мисс Флетчер, можно поговорить с вами минутку. За дверью. - Да, конечно… сэр. - Сьюзан не знала, как. Бросила взгляд на монитор, потом посмотрела на Грега Хейла.
Все звонки принимались единственным оператором на двенадцатиканальный терминал Коренсо-2000. Телефонистка, державшая трубку у уха, мгновенно поднялась и поклонилась, увидев босса. - Садитесь! - рявкнул Нуматака. Она опустилась на стул. - В четыре сорок пять ко мне на личный телефон поступил звонок.
Я отдал лучшие годы жизни своей стране и исполнению своего долга.
Не может быть! - сказала она по-испански. У Беккера застрял комок в горле. Росио была куда смелее своего клиента.
Сьюзан швырнула ему под ноги настольную лампу, но Хейл легко преодолел это препятствие. Он был уже совсем. Правой рукой, точно железной клешней, он обхватил ее за талию так сильно, что она вскрикнула от боли, а левой сдавил ей грудную клетку. Сьюзан едва дышала. Отчаянно вырываясь из его рук, Сьюзан локтем с силой ударила Хейла.
Бринкерхофф посмотрел на мониторы, занимавшие едва ли не всю стену перед ее столом. На каждом из них красовалась печать АНБ. - Хочешь посмотреть, чем занимаются люди в шифровалке? - спросил он, заметно нервничая.
Сегодня днем. Примерно через час после того, как его получила. Беккер посмотрел на часы - 11.
В главный банк данных попал вирус, - сказал Бринкерхофф. - Я знаю, - услышала Сьюзан собственный едва слышный голос. - Нам нужна ваша помощь.