Tetracyclines In Biology Chemistry And Medicine Pdf E-books
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DOI: Abstract PDF. Infectious diseases are a major cause of threat throughout the world which may have concern with microorganisms, specifically bacteria. Various antibiotics are synthesized and used against infectious diseases to mimic the death rate. Many of members of this family also possess some non-antibacterial properties such as anti-inflammatory, immunosuppressant and inhibition of lipase. Various studies reveals structure activity relationship of the tetracycline family, which shows the bioactivity, strength and selectivity to biological target, specifically depends upon modification of lower and upper peripheral zones of tetracycline skeleton.
Antibiotic , chemical substance produced by a living organism, generally a microorganism, that is detrimental to other microorganisms. Antibiotics commonly are produced by soil microorganisms and probably represent a means by which organisms in a complex environment, such as soil, control the growth of competing microorganisms. Microorganisms that produce antibiotics useful in preventing or treating disease include the bacteria and the fungi. Antibiotics came into worldwide prominence with the introduction of penicillin in Since then they have revolutionized the treatment of bacterial infections in humans and other animals. They are, however, ineffective against viruses. In Scottish bacteriologist Alexander Fleming noticed that colonies of bacteria growing on a culture plate had been unfavourably affected by a mold , Penicillium notatum , which had contaminated the culture.
Tetracyclines: Drugs with Huge Therapeutic Potential
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Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. Common side effects include bone marrow suppression , nausea, and diarrhea. Chloramphenicol was discovered after being isolated from Streptomyces venezuelae in
Tetracycline , sold under the brand name Sumycin among others, is an antibiotic used to treat a number of infections. Common side effects include vomiting, diarrhea , rash, and loss of appetite. Tetracycline was patented in and came into commercial use in Tetracyclines have a broad spectrum of antibiotic action. Originally, they possessed some level of bacteriostatic activity against almost all medically relevant aerobic and anaerobic bacterial genera, both Gram-positive and Gram-negative , with a few exceptions, such as Pseudomonas aeruginosa and Proteus spp. However, acquired as opposed to inherent resistance has proliferated in many pathogenic organisms and greatly eroded the formerly vast versatility of this group of antibiotics.