Ophthalmic Preparations Formulation And Evaluation Pdf
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Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology.
- OPHTHALMIC IN-SITU SUSTAINED GEL OF CIPROFLOXACIN, PREPARATION AND EVALUATION STUDY
- Review on Basic Concept for Ophthalmic Preparations
- Preparation and evaluation of nanoparticles for ocular delivery of diclofenac sodium
OPHTHALMIC IN-SITU SUSTAINED GEL OF CIPROFLOXACIN, PREPARATION AND EVALUATION STUDY
Review on Basic Concept for Ophthalmic Preparations
Objective: This work aims to formulate and evaluate an ophthalmic in-situ gel of ciprofloxacin hydrochloride HCl using poloxamer P as a gelling agent and hydroxypropyl methylcellulose HPMC as a viscosity modifier. The objective of this work was to prolong the contact time as the in-situ gel will be converted into a gel upon contact with the cul-de-sac. Methods: Ciprofloxacin HCl ophthalmic in-situ gel was prepared by utilizing P as a temperature-dependent polymer while hydroxypropyl methylcellulose was used as a viscosity modifier. The system was evaluated for physical appearance, pH, drug content, sterility, irritancy and stability. In addition, gelation temperature and a viscosity at different shear rates and different temperatures were studied. The compatibility of the polymer with ciprofloxacin was studied by using fourier transform infrared spectroscopy FTIR. The in vitro release of the drug was also evaluated and supported by a preliminary in vivo test.
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Copy embed code:. Automatically changes to Flash or non-Flash embed. WordPress Embed Customize Embed. URL: Copy. Presentation Description Ophthalmic preparations, advantages, disadvantages, formulation, evaluation, routes of delivery,. They are specialized dosage forms designed to be instilled onto the external surface of the eye topical , administered inside intraocular or adjacent periocular to the eye or used in conjunction with an ophthalmic device.
Preparation and evaluation of nanoparticles for ocular delivery of diclofenac sodium
This book provides a list of concise extemporaneous ophthalmic preparations, and standardizes the formulation of the products by suggesting specific strength, route of administration, appropriate vehicle, and method of preparation. Pharmaceutical industries have greatly expanded their share of ophthalmic drugs in recent years. However, physicians and pharmacists are frequently called to prepare sterile products intended for ophthalmic use due to lack of availability of licensed drugs in the market. This book contains the most appropriate formulation of each medication based on published and documented stability data.
The orally administered acetazolamide has a limited use in glaucoma due to the systemic side effects associated with its use. In order to enhance the bioavailability of the drug, contact time between the drug molecules and the ocular surface was increased using high viscosity, water soluble polymers PVA, HPMC , and by incorporating acetazolamide into an in situ-forming ophthalmic drug delivery system. Moreover, a penetration enhancer EDTA was also used in these formulations to increase the extent of absorption of the drug.
The present work describes the formulation and evaluation of an ophthalmic delivery system of an antibacterial agent, ciprofloxacin, which is used in the treatment of eye infection such as dacrocystitis, bacterial conjunctivitis, corneal ulceration and blepharitis, based on the concepts of ph-triggered in-situ gelation, thermo reversible gelation and Ion activated system. Poly acrylic acid Carbopol was used as the gelling agent in combination of hydroxy propyl methylcellulose, which acted as a viscosity-enhancing agent. Gellan gum Gelrite is an anionic exocellular polysaccharide by the bacterium pseudo Monas elodea, having the characteristic property cation-induced gelation 0.
Background and objective: Ocular drug delivery research is challenging due to the presence of anatomical and physiological barriers.
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